2C-P

2-(2,5-dimethoxy-4-propylphenyl)ethanamine

Overview

2C-P belongs to Psychedelics / Phenethylamines / 2C series.

Key safety note: 2C-P is among the most potent and longest-acting 2C psychedelics, with a narrow margin between an active and an excessive dose: small errors can produce intense, frightening and very prolonged (10–16 h) experiences.[2]
Effects
Subjective effects vary. What a substance feels like depends on dose, individual physiology, mindset, and setting. The points below describe commonly reported effects, not guaranteed, uniform, or desirable outcomes.
  • Slow, gentle onset that builds into strong, long-lasting psychedelic effects
  • Pronounced visual and perceptual changes at active doses
  • Marked stimulation and physical energy, which can become uncomfortable or taxing
  • Very long duration (10–16 h), so difficult experiences can be extended
Dosing & duration
Harm-reduction note: These are commonly cited reference ranges, not a recommendation or a “safe” dose. Potency, purity, body chemistry, tolerance, and drug combinations vary widely. Start low, go slow, wait for full effects before redosing, and never assume an unknown product matches these figures. Missing data is not evidence of safety.

Oral. 2C-P is unusually potent for a 2C compound and the active-to-heavy dose margin is narrow: careful, accurate low dosing and long waiting before any redose are essential.

Dose ranges

Oral

6–10 mg

Duration

onset

1–2 h (slow, gentle build-up)

peak

≈3 h

total

10–16 h

Chemical & Physical Properties
FormulaC13H21NO2
Molar mass223.31 g/mol
StateSolid (usually the hydrochloride salt, white crystalline)
Melting point207–209 °C (hydrochloride salt, sinters from ~183 °C)
Boiling pointNot reported
DensityNot reported
Vapor pressureNot reported
pKaNot reported
LogP2.5 (predicted, XLogP3)
SolubilityNot reported
Refractive indexNot reported
Identifiers & Synonyms
CASNot reported
CAS (enantiomer)
PubChem CID44350080
InChIKeyPZJOKFZGPTVNBF-UHFFFAOYSA-N
InChIInChI=1S/C13H21NO2/c1-4-5-10-8-13(16-3)11(6-7-14)9-12(10)15-2/h8-9H,4-7,14H2,1-3H3
SMILESCCCC1=CC(=C(C=C1OC)CCN)OC

Synonyms

  • 2,5-dimethoxy-4-propylphenethylamine
  • 4-propyl-2,5-dimethoxyphenethylamine
  • 2C-P
Pharmacodynamics & Biochemistry

Serotonergic phenethylamine psychedelic acting primarily as a potent 5-HT2A receptor agonist with high functional efficacy. Also engages 5-HT2C, 5-HT2B, 5-HT1A and adrenergic receptors. One of the most potent and longest-acting members of the 2C series, with a narrow margin between an active and an excessive dose.

Biological targets

  • 5-HT2A
  • 5-HT2C

Binding & functional measurements

TargetMeasurementSpecies
5-HT2A receptorKi 8.1 ± 1.0 nMHuman
5-HT2C receptorKi 40 ± 5.0 nMHuman
5-HT2B receptorEC50 130 ± 10 nM
Emax 72 ± 18%		Human
α2-adrenoceptorKi 90 ± 10 nMHuman
5-HT1A receptorKi 110 ± 40 nMHuman
D2 receptorKi 2,300 ± 700 nMHuman
α1A-adrenoceptorKi 3,500 ± 500 nMHuman
D3 receptorKi 5,200 ± 500 nMHuman
D1 receptorKi 8,400 ± 900 nMHuman
TAAR1Ki 20 ± 5.0 nMRat
5-HT2A receptorEC50 90 ± 60 nM
Emax 63 ± 5%		Human
TAAR1EC50 4,200 ± 500 nM
Emax 72 ± 11%		Human
TAAR1EC50 560 ± 230 nM
Emax 91 ± 27%		Mouse
TAAR1Ki 280 ± 30 nMMouse
TAAR1EC50 30 ± 22 nM
Emax 84 ± 8%		Rat
Pharmacokinetics
BioavailabilityNot reported
TmaxNot reported
Half-lifeVery long
VdNot reported
Protein bindingNot reported
MetabolismHepatic
ExcretionNot reported
Toxicology & Safety
Harm-reduction note: Toxicity and risk depend on dose, route, purity, combinations, setting, and individual health factors. Missing harms should never be interpreted as evidence of safety.

Not reported

2C-P is among the most potent and longest-acting 2C psychedelics, with a narrow margin between an active and an excessive dose: small errors can produce intense, frightening and very prolonged (10–16 h) experiences. Acute effects can include severe anxiety, confusion and perceptual overwhelm, alongside sympathomimetic and vasoconstrictive effects such as tachycardia, hypertension, mydriasis, nausea and a heavy body load. Seizures and serious toxicity have been reported at high doses. Risk rises further in hot or crowded settings, with adulteration, and in combination with stimulants or other serotonergic drugs. Formal human toxicity data are very limited, and limited literature must never be read as evidence of safety.[2]

Legal Status
Legal note: Legal status can change over time and may vary by country, region, formulation, analogue status, prescription context, and enforcement practice. Always confirm with current official sources before relying on this section.
Interactions & Contraindications

Drug interactions

SSRIs, SNRIs, Lithium, Tramadol, Other serotonergic drugs Can add to serotonergic load and, in principle, raise the risk of serotonin toxicity.
MAOIs May intensify and prolong effects unpredictably, warranting particular caution.
Stimulants (amphetamines, cocaine) Compound cardiovascular strain, anxiety, vasoconstriction and overheating risk.

Contraindications

Personal or family history of psychosis, schizophrenia or bipolar disorder
Cardiovascular disease, hypertension or arrhythmia significant or uncontrolled disease or hypertension.
Concurrent MAOI, SSRI/SNRI or other serotonergic medication concurrent MAO inhibitors.
Hot, dehydrating environments (overheating risk) or heavy stimulant co-use.
Usage & Context
  • Research.
Sources & Evidence

Further Information